双歧杆菌三联活菌联合芪蓉润肠口服液治疗高原(2)
【作者】网站采编
【关键词】
【摘要】有研究发现,功能性便秘患者粪便中肠道菌群存在变化,正常菌群含量显著降低,致病菌显著增多[7-8]。肠道菌群的改变会造成肠道微生态环境及肠道功能
有研究发现,功能性便秘患者粪便中肠道菌群存在变化,正常菌群含量显著降低,致病菌显著增多[7-8]。肠道菌群的改变会造成肠道微生态环境及肠道功能的一系列变化,进而引起肠道功能变化产生腹胀、便秘等临床症状,推测功能性便秘可能与肠道菌群失衡相关[9]。有研究发现,通过补充正常菌群,可恢复肠道动力,改善便秘症状,其机制可能与纠正肠黏液代谢异常和修复屏障损伤,以及恢复肠动力有关[10-11]。本研究中,B组在A组的基础上联合应用双歧杆菌三联活菌。双歧杆菌三联活菌胶囊是一种临床普遍应用的益生菌,由嗜酸乳杆菌、长型双歧杆菌及粪肠球菌组成,应用后可以补充肠道正常微生物群,平衡胃肠道菌群微生态,保护肠道屏障;可以产生短链脂肪酸,降低肠腔pH值,改善肠道环境;也可以抑制病原菌生长,减少肠源性毒素的合成,保持胃肠道的蠕动功能[12],从而有效改善便秘症状[13]。本研究中,B组总体便秘症状和生活质量各评分明显优于A组,提示芪蓉润肠口服液联合双歧杆菌三联活菌能明显改善高原寒区便秘患者症状。
综上所述,芪蓉润肠口服液联合双歧杆菌三联活菌是治疗高原寒区功能性便秘患者的优化治疗策略,但该治疗方案还需更大样本的研究证实。
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